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KMID : 0361119960100010145
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Korean Journal of Transplantation
1996 Volume.10 No. 1 p.145 ~ p.150
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A Case of De Novo Cyclosporine A Associated Hemolytic Uremic Syndrome in Renal Transplant Recipients
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Kim Yong-Lim
Kwon Tae-Hwan
Cho Dong-Gyu
Kwak Jung-Sik
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Abstract
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The cyclosporine A associated hemolytic uremic syndrome has been reported previously in recipients of bone marrow, cardiac, liver and renal allografts as a dramatic but relatively rare disorder. This syndrome, accompanied by platelet fibrin thrombi in glomerular capillaries, is likely to occur when the plasma levels of cyclosporine A are high and during the first weeks after transplantation. The outcome is poor. Some therapies effective in other forms of hemolytic uremic syndrome have been tried, but only a minority of patients recovered renal function while most lost their graft in a matter of weeks. Early recognition of the syndrome and discontinuation of cyclosporine A has occasionally led to reversal of the syndrome.
We report a case of de novo cyclosporine A associated hemolytic uremic syndrome occurring within first week after kidney retransplantation, in which the patient was successfully treated with decreasing the dose of cyclosporine A and intensive plasma exchange.
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KEYWORD
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Renal transplantation, Cyclosporine, Hemolytic uremic syndrome, Renal biopsy,
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